When do you know when it is time to shut the door? When your house has flooded to the second floor? When you've scrambled up top of a dresser and are sitting there with your arms around your knees, trembling?
Some things can come into your life with so much flavor and so many nutrients. If it spoils, it won't be good for you no matter how you try to ingest it. You will have a bad taste in your mouth. It will wake you in the middle of the night, ill. Sick to your stomach.
Does this remind you of a relationship you have? The longer you wait to close it, the harder it will be to get there. The more you will struggle to dive down there to shut it, the more you will struggle to clean up the remnants.